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Large-scale trials are only available for BH 4 , sepiapterin or sapropterin in phenylketonuria (Muntau et al., 2024), an autosomal recessive disorder caused by deficiency of phenylalanine hydroxylase, leading to hyperphenylalaninemia, developmental delay, behavioral problems, and reduced quality of life ( Approaches with preclinical evidence only Promoting transcriptional regulation of eNOS Several compounds have been identified to enhance eNOS transcription and promote NO production

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Loren Pickart in 1973, its initial identification was in relation to its ability to stimulate the healing of wounds

Under normal physiological conditions, glutathione is mainly degraded to glutamate and Cys-Gly dipeptide by Ggt1, which belongs to the N-terminal nucleophile hydrolase family